ZIP code 22645 is officially located in the state of Virginia, primarily serving the city of Middletown. It falls under the administrative jurisdiction of Frederick County. When planning mail delivery, logistics routing, or demographic research, 22645 operates within the Eastern Time (ET) timezone and supports the 590 area codes.
According to the latest US Census Bureau and American Community Survey (ACS) datasets, the total population residing within the 22645 ZIP Code Tabulation Area is approximately 29,990. Understanding local economics is critical for market analysis; the median household income in this postal area sits at $105,645.